Formic Acid
Formic acid (HCOOH) is naturally-occurring, flammable, corrosive, organic, and the simplest carboxylic acid. Used as a hydride ion source in synthetic organic chemistry, a mobile phase component in HPLC, a preservative/antibacterial agent in agriculture, etc.
Formic or methanoic acid (CAS: 64-18-6; PubChem ID: 284) is a colorless organic acid with the formula HCOOH. At ambient temperatures, it has a strong, penetrating odor, like acetic acid. Used in chemical synthesis as an intermediate, this simple carboxylic acid is miscible in water and most organic solvents and is somewhat hydrocarbon-soluble.
Formic acid occurs naturally in the venom of some ants and bees. Formate, the conjugate base of formic acid, also occurs naturally in bodily fluids following methanol poisoning.
Formic acid is a source of hydride ion in synthetic organic chemistry, as in the Eschweiler-Clarke and Leuckart-Wallach reactions. It is also a useful component of the mobile phase in reversed-phase high-performance liquid chromatography (RP-HPLC) for peptides, proteins, and intact viruses.
Although formic acid is easily metabolized and eliminated, it can have toxic effects. Methanol metabolism produces formic acid and formaldehyde, which are responsible for the optic nerve damage that results from methanol poisoning. Chronic exposure in humans may cause kidney damage and skin allergies in some people.
In diluted forms, formic acid and formate esters are used as artificial flavorings and perfume additives. In higher concentrations, formic acid is flammable, and skin and eye contact with concentrated liquid or vapors is dangerous.
In agriculture, formic acid is used as a preservative and antibacterial agent and by beekeepers to kill mites. It is useful in leather tanning, textile dyeing and finishing, and in rubber production. Formic acid replaces mineral acids in limescale removers and other cleaning products.
Medchemexpress LLC Zelavespib formic | 97.4% | 558.39 | 25 MG
Zelavespib formic (PU-H71 formic) is a potent Hsp90 inhibitor with an IC50 value of 51 nM for Hsp90 in MDA-MB-468 cells. It is intended for research use only.
- Potent Hsp90 inhibitor
- Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO
- Available in various solid forms (5 mg, 10 mg, 25 mg, 50 mg, 100 mg)
- Also available in solution form (10 mM * 1 mL in DMSO)
- Cited in 12 publications
- Related to various compound screening libraries and small molecules
- Clinical trials listed for Metastatic Breast Cancer, Accelerated Phase MPN, Blast Phase MPN, Metastatic Solid Tumor, Lymphoma, Myeloproliferative Neoplasms (MPN), Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (Post-PV MF), Post-Essential Thrombocythemia Myelofibrosis (Post-ET MF)
eMolecules 64-18-6 | Formic Acid, ACS Grade | Oakwood Chemicals | MFCD00003297 | 46.025 | CH2O2 | 88.000 | OC=O | 4kg | 480143865
Formic Acid, ACS Grade | Oakwood Chemicals | 64-18-6 | MFCD00003297 | 46.025 | CH2O2 | 88.000 | OC=O | 4kg | 480143865
Medchemexpress LLC Bisindolylmaleimide IX formic | 00-00-0 | 96.0% | 503.57 g/mol | C26H25N5O4S | 5 MG
Ro 31-8220 formic is the formic acid salt of bisindolylmaleimide IX, a potent protein kinase C (PKC) inhibitor provided for laboratory research. The compound is supplied as a small, high-purity solid with manufacturer storage and handling guidance available on the product datasheet.
- Potent PKC inhibitor with low-nanomolar activity.
- Formic acid salt for improved handling and solubility options.
- High purity (≈96.0%).
- Orange to red solid appearance.
- Supplied as a 5 mg vial for research use.
- Recommended storage: sealed, away from moisture, at -20 °C; in solvent, store at -80 °C (up to 6 months) or -20 °C (up to 1 month).
Medchemexpress LLC Pkciota-IN-2 formic | 99.0% | 402.36 | C25H23N5O3 | 5 MG
PKCiota-IN-2 formic is a research-grade small-molecule inhibitor targeting atypical protein kinase C iota (PKCι). It exhibits low-nanomolar potency and a defined selectivity profile, and is supplied as a powder for laboratory use with recommended sealed, refrigerated storage.
- Low-nanomolar potency against PKCι (IC50 2.8 nM).
- Inhibits PKCα and PKCε with higher IC50s (71 nM and 350 nM).
- High chemical purity (99.04%).
- Molecular weight 402.36 g·mol⁻¹.
- Provided as a powder with refrigerated storage recommended.
- Available in small research pack sizes (including 5 mg).
Sigma Aldrich Fine Chemicals Biosciences Formic acid European Pharmacopoeia (EP) Reference Standard | 64-18-6 | MFCD00003297 |
Formic acid European Pharmacopoeia (EP) Reference Standard | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 |
Medchemexpress LLC CCT367766 (formic) | 98.1% | 992.42 | 25 MG
CCT367766 (formic) | 98.1% | 992.42 | 25 MG
Medchemexpress LLC SJ1008030 formic | 2863634-96-0 | 97.7% | 919.96 | 50 MG
SJ1008030 formic is a JAK2 PROTAC that selectively degrades JAK2, making it suitable for leukemia research. It inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM.
- Selectively degrades JAK2
- Inhibits MHH-CALL-4 cell growth
- Useful for leukemia research
- Degrades JAKs, GSPT1, and IKZF1 in a dose-dependent manner
- Inhibits JAK-STAT signaling pathway
Medchemexpress LLC LCC-12 (formic) | 3029253-76-4 | 99.9% | 460.57 | 1 MG
LCC-12 formic is a dimer of metformin that targets mitochondrial copper(II), leading to a decrease in the NAD(H) pool and modulation of inflammatory responses. It reduces inflammation in mouse models of bacterial and viral infections and serves as a tool for investigating metabolic diseases through its effects on cell plasticity and epigenetic programming.
- Targets mitochondrial copper(II)
- Leads to a decrease in the NAD(H) pool
- Modulates inflammatory responses
- Reduces inflammation in mouse models of bacterial and viral infections
- Serves as a tool for investigating metabolic diseases
- Affects cell plasticity and epigenetic programming
Medchemexpress LLC Dl-01 formic | 2964513-44-6 | 98.5% | 1144.30 | C56H73N9O15S | 5 MG
DL-01 formic is a drug-linker conjugate used in the synthesis of antibody-drug conjugates (ADCs) and related research applications. It is supplied as a high-purity solid for laboratory research use only and should be handled and stored according to the product datasheet and safety documentation.
- Drug-linker conjugate for ADC synthesis
- High purity (approximately 98.5%) solid, white to light yellow
- Molecular formula C56H73N9O15S and molecular weight 1,144.30
- CAS number 2964513-44-6
- Store at -80°C, protect from light, store under nitrogen
Medchemexpress LLC CBI1 formic | 461.40 | 5 MG
CBI1 formic is a covalent BAX inhibitor. It selectively derivatizes BAX at C126 and inhibits BAX activation by triggering ligands or point mutagenesis. CBI1 formic blocks t-2-hex lipidation and oligomerization of BAX and inhibits BAX activation induced by BH3 ligands, F116A mutagenesis or t-2-hex.
- Covalent BAX inhibitor
- Selectively derivatizes BAX at C126
- Inhibits BAX activation by triggering ligands or point mutagenesis
- Blocks t-2-hex lipidation and oligomerization of BAX
- Inhibits BAX activation induced by BH3 ligands, F116A mutagenesis or t-2-hex
LAB ALLEY Formic Acid 99% LC/MS Grade
Formic Acid is the simplest carboxylic acid containing only one carbon. It is a colorless liquid with a pungent aroma. It is about 10 times stronger than Acetic Acid. The high acidity level and reducing nature of this compound makes it different from other carboxylic acids. LC/MS is a versatile technique that combines the physical separation property of Liquid Chromatography with the mass analysis property of Mass Spectroscopy. LC-MS Grade Formic Acid is high-purity solvent for preparing elution solvents for HPLC separations of protein and peptides. LC/MS Grade Formic Acid is well suited as a chromatography additive for use in LCMS and HPLC applications.
Sigma Aldrich Fine Chemicals Biosciences Formic acid reagent grade, >=95% | 64-18-6 | MFCD00003297 | 100ML
Formic acid reagent grade, >=95% | Purity: >=95% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 100ML
Medchemexpress LLC MRTX-EX185 formic | 2988148-70-3 | 97.23% | C34H35FN6O4 | 1 ML
MRTX-EX185 formic is a potent KRAS (G12D) inhibitor with an IC50 of 90 nM. It binds to both GDP-loaded and active GNP states of KRAS and KRAS (G12D). This compound exhibits broad-spectrum binding properties and can be utilized for studying various RAS-driven tumors, such as pancreatic cancer.
- Suppresses cell proliferation in KRAS (G12D)-driven SW-1990 pancreatic cancer cells with an IC50 of 70 nM.
- Non-toxic to non-KRAS-dependent cell lines (HEK293 cells).
- Significantly inhibits ERK phosphorylation (p-ERK) in KRAS(G12C)-driven cell lineages.